What Is Diosmin Powder?
Diosmin powder is a semi-synthetic flavonoid compound derived from hesperidin, a naturally occurring glycoside abundant in citrus fruits such as oranges, lemons, and bitter oranges (Citrus aurantium). Widely recognized in pharmaceutical and nutraceutical industries as a potent venotonic and vascular protective agent, Diosmin has established itself as a key active pharmaceutical ingredient (API) for supporting venous health and microcirculatory function.
The Extract Factory supplies pharmaceutical-grade Diosmin powder manufactured under GMP-compliant conditions, offering bulk and wholesale quantities for ingredient manufacturers, supplement brands, formulators, and international distributors seeking a reliable source of high-purity citrus-derived flavonoid raw material.
Botanical Source & Production Overview
Primary Source: Diosmin is obtained through the alkaline isomerization and partial hydrolysis of hesperidin, which is naturally concentrated in the peel, pulp, and segment membranes of citrus species. The raw botanical material is predominantly sourced from mature citrus fruits cultivated in major growing regions known for consistent flavonoid content.
Extraction & Manufacturing Process:
The production of Diosmin powder typically follows a multi-step extraction and purification workflow:
- Raw Material Preparation — Dried citrus peel or hesperidin-rich extract is milled to a uniform particle size.
- Alkaline Isomerization — Hesperidin undergoes controlled alkaline treatment to convert the flavanone glycoside structure into the flavone aglycone, Diosmin.
- Purification & Crystallization — The crude Diosmin is subjected to repeated filtration, washing, and recrystallization to achieve the target purity specification.
- Drying & Milling — The purified compound is dried under controlled temperature conditions and milled to a consistent mesh size (typically 80 mesh or finer) for uniform handling and formulation compatibility.
This controlled manufacturing approach ensures batch-to-batch consistency, a critical requirement for pharmaceutical and nutraceutical formulators who rely on predictable raw material performance.
Diosmin Powder Specifications
| Parameter | Detail |
|---|---|
| Product Name | Diosmin Powder |
| CAS Number | 520-27-4 |
| Active Compound | Diosmin (flavone glycoside) |
| Assay (Purity) | 90% – 102% |
| Extract Ratios Available | 5:1, 10:1, 20:1 |
| Appearance | White to off-white fine powder |
| Mesh Size | 80 mesh (customizable) |
| Analytical Method | HPLC / UV |
| Solubility | Slightly soluble in water; soluble in alkaline solutions and organic solvents such as DMSO and dimethylformamide |
| Storage | Cool, dry place; protect from light and heat; do not freeze |
| Shelf Life | 2 years (under proper storage conditions) |
| Packaging Options | 1 kg/bag, 25 kg/drum, or custom |
Pharmacological Function & Mechanism of Action
Diosmin has been extensively studied for its multifaceted vascular protective properties. Below is a detailed breakdown of its three principal mechanisms:
1. Venotonic Activity — Enhancing Venous Wall Tension
Diosmin exerts a direct contractile effect on venous smooth muscle by prolonging the vasoconstrictor action of norepinephrine on the venous wall. This results in a sustained increase in venous tone and improved venous return. Notably, even under elevated temperature or acidic physiological conditions, Diosmin demonstrates a stronger venoconstrictive response compared to related flavonoids such as rutin. Importantly, Diosmin exhibits selective affinity for the venous system and does not produce significant effects on arterial blood vessels, making it a targeted venous support compound.
2. Microcirculation Support — Reducing Capillary Permeability
At the microvascular level, Diosmin modulates several key inflammatory and rheological pathways:
- Leukocyte-Endothelial Interaction: Diosmin significantly reduces the adhesion and migration of white blood cells to vascular endothelial cells, a critical step in the inflammatory cascade.
- Inflammatory Mediator Modulation: It inhibits the release of histamine, slow-reacting substances (SRS), complement components, leukotrienes, and prostaglandins — all of which contribute to vascular leakage and tissue swelling.
- Oxidative Stress Reduction: Diosmin scavenges excess free radicals, protecting endothelial integrity.
- Blood Rheology: By lowering blood viscosity and enhancing red blood cell deformability and velocity, Diosmin helps prevent microcirculatory stasis and congestion.
3. Lymphatic System Support — Promoting Lymphatic Drainage
Diosmin stimulates lymphatic vessel contractility and accelerates lymphatic drainage velocity. This facilitates the efficient removal of interstitial fluid, improves lymphatic reflux, and contributes to a measurable reduction in edema — particularly relevant for chronic venous insufficiency and related conditions.
Key Functional Benefits of Diosmin Powder
| Benefit | Description |
|---|---|
| Venous Health Support | Strengthens venous tone and reduces venous pooling |
| Capillary Protection | Decreases capillary fragility and abnormal permeability |
| Anti-Edema Action | Promotes lymphatic drainage and reduces tissue swelling |
| Anti-Inflammatory Support | Inhibits multiple inflammatory mediator pathways |
| Antioxidant Activity | Neutralizes free radicals that damage vascular endothelium |
| Improved Microcirculation | Enhances red blood cell flow and reduces blood viscosity |
| Low Toxicity Profile | Demonstrates a favorable safety margin compared to synthetic alternatives |
Diosmin's role is often described in terms of "Vitamin P activity" — a historical term referring to flavonoids that strengthen blood vessel walls. Compared with rutin and hesperidin, Diosmin demonstrates superior efficacy in reducing capillary fragility with a notably low toxicity profile.
Industry Applications
Diosmin powder serves as a versatile raw material across multiple sectors:
- Pharmaceuticals: Used as an API or excipient-grade ingredient in oral medications for chronic venous insufficiency (CVI), hemorrhoidal disease, and as adjunctive support in hypertension and arteriosclerosis management.
- Nutraceuticals & Dietary Supplements: Incorporated into capsule, tablet, and powder-based venous health, circulation support, and cardiovascular wellness formulations.
- Functional Foods & Beverages: Added to specialized health food products targeting vascular and circulatory wellness.
- Cosmeceuticals: Explored in topical formulations for its microcirculation-enhancing and anti-inflammatory properties.
- Veterinary Applications: Used in some animal health formulations for circulatory support.
Formulators value Diosmin powder for its compatibility with a broad range of excipients and its stability under standard manufacturing conditions, making it suitable for both direct compression and capsule-filling processes.
Quality Assurance, Certifications & Manufacturing Standards
The Extract Factory is committed to delivering Diosmin powder that meets the most demanding quality expectations of global B2B buyers. Our quality management framework encompasses the following:
| Quality Attribute | Detail |
|---|---|
| Manufacturing Standard | GMP-compliant facility |
| Purity Testing | HPLC and UV spectrophotometric analysis for each batch |
| Certifications Available | ISO, HACCP, KOSHER |
| Organic Compliance | Ingredients available meeting National Organic Program (NOP) and European Union (EU) organic standards; IFOAM-aligned organic certification available |
| Traceability | Full batch traceability from raw botanical sourcing through final packaging |
| Cleanliness & Safety | Exceeds industry benchmarks for purity, heavy metal limits, microbial control, and residual solvent compliance |
Every production lot is accompanied by a Certificate of Analysis (COA) documenting assay values, mesh size, moisture content, microbiological status, and heavy metal screening results.
Custom OEM & Private Label Services
The Extract Factory provides comprehensive customization options for Diosmin powder, enabling brands and manufacturers to receive tailored product solutions:
| Service Type | Available Options |
|---|---|
| Raw Powder Packaging | 100 g, 200 g, 250 g, 300 g — any custom size supported |
| Capsule Formulation | 500 mg, 600 mg per capsule — custom dosages available |
| Tablet Formulation | 500 mg, 1000 mg per tablet — custom dosages available |
| Subcontract Manufacturing | Full turnkey production from raw Diosmin powder to finished dosage form |
| Free Sample Program | Product samples available for quality evaluation prior to bulk orders |
Our OEM capabilities extend to specification adjustment (e.g., 90%, 95%, 98% purity or custom extract ratios), private labeling, and co-packaging — giving international buyers the flexibility to launch Diosmin-based products under their own brand with confidence.
Packaging, Shipping & Storage Information
| Detail | Specification |
|---|---|
| Small Quantity | 1 kg net weight per aluminum foil bag, packed inside a paper carton (gross weight ~1.2 kg) |
| Bulk Quantity | 25 kg net weight per fiber drum with double inner plastic bags (gross weight ~28 kg; drum dimensions: 510 mm height × 350 mm diameter) |
| Custom Packaging | Available upon request — OEM bag, drum, or pallet configurations |
| Storage Conditions | Store in a cool, dry environment. Avoid freezing. Protect from direct sunlight and excessive heat. |
| Shelf Life | 24 months from date of manufacture when stored properly |
| Shipping Methods | International express courier (UPS, EMS), air freight, and sea freight — flexible to buyer logistics requirements |
Why Choose The Extract Factory for Diosmin Powder?
- Consistent High Purity: Batch-tested Diosmin powder at 90%–102% assay, verified by HPLC/UV.
- GMP-Managed Production: Manufactured in a facility that adheres to Good Manufacturing Practice guidelines.
- Global Export Capability: Experienced in international trade documentation, customs compliance, and multi-region shipping.
- Competitive Wholesale Pricing: Direct manufacturer pricing eliminates middleman markups for distributors and brand owners.
- Technical Support: Our team provides formulation guidance, specification matching, and regulatory documentation assistance.
- Responsive Communication: Prompt inquiry handling and dedicated account support for repeat and long-term buyers.
Get In Touch
Whether you are a pharmaceutical ingredient distributor, a supplement brand looking for a trusted Diosmin powder source, a contract manufacturer requiring custom specifications, or a wholesale buyer evaluating citrus flavonoid raw materials, The Extract Factory is ready to support your sourcing needs.
Contact us for product inquiries, technical data sheets, sample requests, or custom OEM quotations:
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